Optimizing strategies for Meningococcal C disease vaccination in Valencia, Spain

June 12th, 2013

introduction

This website includes additional information and simulations of the paper Optimizing strategies for Meningococcal C disease vaccination in Valencia, Spain, co-authored by L. Pérez-Breva, R. J. Villanueva, J. Villanueva-Oller, L. Acedo, F. J. Santonja, J. A. Moraño, R. Abad, J. A. Vázquez and J. Díez-Domingo published in the journal BMC Infectious Diseases 2014, 14:280 (May 2014) doi:10.1186/1471-2334-14-280.


There are four parts.



Vaccine protection evolution

In this part we present the results obtained to determine how vaccinated individuals lose their protection over the time depending on the age they were vaccinated and their current age.


Simulation of current situation

Here, we present a simulation to see how the protection evolves over the time per age groups with the current vaccination schedule in Valencia, i.e., at 2, 6 and 18 months old.


Simulation of optimum vaccination schedule

In this part, we show a simulation where, in January 2014, changes the current vaccination schedule by the optimum one, that is, at 2, 12 months and 12 years old.


Simulation of optimum vaccination schedule plus catch-up vaccination

In the previous simulation, an undesired effect due to the change of vaccination schedule arises, consisting of the drop of protection in teenagers. In this part, we propose and simulate a catch-up vacination with a coverage of 30% from January 2014 to December 2014 in 13-15 year old teenagers.

  

 

Acknowledgements

This work has been supported by the grant FIS PI- 10/01433 from the Instituto de Salud Carlos III and the grant PAID-06-11 ref: 2087 from the Universitat Politècnica de Valéncia. An agreement between CSISP- FISABIO and Baxter Laboratories for epidemiological studies of meningococcal C disease is also acknowledged.